Unique AutoTFF™075 is a flexible and automated lab scale tangential flow filtration(TFF)system that can be used with hollow fibers or cassette filters for concentration, diafiltration or clarification of samples. It is widely used in biological product process, such as antibodies, recombinant proteins, mRNA, nucleic acids, viral vectors, etc. Its flexible configuration allows for manual operation and highly automated process control. Combined with a comprehensive management system, it is suitable for small-scale process development, process scale up study, and sample preparation.
Automatic TMP control, weighing, feeding, precise control of concentration ratio and diafiltration volume
Compact design, small recirculation volume, to meet high concentration requirements
The User friendly control software offers easily recipe setup, operation control, data recording and user management
Optional permeate pumplfor comprihensive microfiltration processe control
High automation with pre-defined method modules, recipe and recipe sequence
Optional conductivity sensor, pH, UV, for comprehensive process monitoring
Adapt to different type of cassette filters and hollow fibers
| Method Module | Function | ||||||||
| Filling | Add a certain amount of liquid to the circulation vessel | ||||||||
| Water flux test | Can automatically test water flux based on defined pressure/crossflow conditions | ||||||||
Clarification / Concentration | Concentrate the feed liquid to the defined volume or concentration factor | ||||||||
| Diafiltration | Constant volume diafiltration with continuouse feed entill predefined endpoint, eg. Diltiltration volume, conductivity, pH | ||||||||
| Harvest/Drain | Harvest the liquid through the harvesting port or outlet valve | ||||||||
| CIP | Used for system cleaning | ||||||||
| Flush | Flush the system with water, buffer or other solutions | ||||||||
| Pause | System pause | ||||||||
| Dimensions(LxDxH,mm) | 580 x 355 x 640 (filter holder not included) | ||||||||
| Electrical requirements | 240VAC, 50-60Hz | ||||||||
| Weight | 48kg(include 0.1m² filter holder) | ||||||||
| Power | 150W | ||||||||
| System language | English,Chinese | ||||||||
| Ambient temperature | 2-35°C | ||||||||
| Filtration area | 50cm²-0.1m²(The specific filtration area can be varied with different filters) | ||||||||
Maximum feed pressure | 5bar | ||||||||
| Minimum recirculating volume | 20ml | ||||||||
| Process temperature | 2-50°C | ||||||||
| Feed pump flow rate | 0-700ml/min | ||||||||
| Retentate pump flow rate | 0-600ml/min | ||||||||
| Permeate pump flow rate | 0-300ml/min | ||||||||
Recirculation vessel volume | 1000ml | ||||||||
| Stirring speed | 0-300rpm | ||||||||
| Pressure sensor | Detection range: 0-5Bar | ||||||||
| Conductivity sensor | Detection range: 0-999.999ms/cm | ||||||||
| Temperature sensor | Integrated in conductivity sensor, detection range: 0-99℃ | ||||||||
| pH | Detection range: 1-14 | ||||||||
Retentate and filtration weighing | 0-6kg | ||||||||
| Filter holder | 1 ABS multifunctional holder for 50cm ² Capsule capsule or hollow fiber filters with a diameter no more than 50mm | ||||||||
| Tube&Connector | Luer Lock | ||||||||
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